Formulated Dosage Forms

GYNEFOL

COMPOSITION
Each Serving size: 1 film coated tablet contains
N-Acetyl cysteine 600mg
Myo Inositol 2mg
Melatonin 1.5 mg
Calcium L-5-Methyltetrahydrofolate 1mg

PRODUCT DESCRIPTION

Gynefol Tablets are unique formulation of fertility product with essential nutritional supplements. Totally it is a boon for the females who are trying to conceive and also for pregnant womens.

N-ACETYL CYSTEINE (NAC)
N-acetyl-cysteine (NAC) is a stable derivative of the sulfur-containing amino acid cysteine and an antioxidant that is needed for the production of glutathione, one of the body’s most important natural antioxidants and detoxifiers. While cysteine is found in high protein foods, n-acetyl cysteine is not. A large body of evidence supports the use of NAC in women with PCOS.

Women with PCOS frequently have an abnormally high insulin response to sugars and refined starches. In Restoring Fertility, NAC may also be useful for improving fertility in women with PCOS.

How Does N-Acetylcysteine Boost Fertility?
Among other things, NAC is an antioxidant, meaning it has the ability to reduce oxidative stress in the body. When it comes to fertility, oxidative stress is one of the last things you want, so having a good antioxidant in your supplement regimen is important. NAC has been clinically proven to reduce the amount of DNA damage in sperm purposely treated with reactive oxygen species, mimicking the benefits NAC would have on naturally occurring free radicals.

How do I know if I should use N-Acetylcysteine to help get pregnant?
For most, NAC is a safe way to help heal and protect reproductive tissues from oxidative stress. You should always consult with your fertility treatment provider before beginning any supplement. Since oxidative stress is a known factor in diagnosing infertility, it makes sense that NAC could help boost chances of conception. Supplementation with NAC would be particularly useful for those with a history of smoking or above-average alcohol consumption, as said activities tend to increase oxidative stress in the body. Women with diminishing ovarian reserve, particularly those over the age of 35, could benefit from NAC for overall reproductive health.

What is the suggested dosage of N-Acetylcysteine for fertility?
In order to benefit from NAC, it should be taken at doses of no more than 500 milligrams per day until healthy conception. Several studies have established the safety of NAC taken at high doses for extended periods of time (3-5 months). Although NAC has shown to be harmless on offspring in animal studies, research is lacking on effects of NAC on pregnant women, so it should only be taken after successful conception if directed to do so by a fertility specialist.

How successful is N-Acetylcysteine?
Most of the research on N-Acetylcysteine for fertility is in the context of women with polycystic ovary syndrome (PCOS). NAC is known to help protect against DNA damage, which is an added benefit when it comes to preparing for a healthy pregnancy. Additionally, NAC has been acknowledged as a beneficial supplement for sperm health, making it a fertility supplement for men also. Although there is room for further research, the benefits of NAC are slowly being recognized by the fertility community as a helpful supplement.

Myo Inositol
Myo Inositol Supplementation restores normal ovulatory activity, increases fertilization rate, prevents spina bifida birth defect, Increases peak progesterone. Myo Inositol reduces the negative effects of hyperglycemia on embryonic growth. Myo Inositol restores normal ovulatory activity and fertility in women with PCOS, Myo Inositol improves egg quality and pregnancy rate in women with failed IVF. Inositol improved pregnancy rate and lowered cancellation rate in PCOS infertility patients. Myo Inositol lowers testosterone, increases SHBG and progesterone, and improves insulin sensitivity. Myo Inositol begins working within one week, restores ovulation, induces weight loss

Myo Inositol lowers testosterone, FSH, LH, cholesterol, and insulin resistance. High insulin associated with low inositol, regardless of PCOS or obesity , Myo Inositol is necessary for insulin effectiveness .

How does Inositol Work to Boost Fertility?
Research suggests a positive correlation between levels of Myo Inositol and egg quality. A 2001 study featured 53 infertile couples who supplemented with Myo Inositol. The results showed that the better quality eggs exhibited higher concentrations of Myo Inositol than poorer quality eggs. For women with irregular menstrual cycles, Inositol has been shown to help restore normal cycles when taken in conjunction with folic acid.

How do I know if I should use Inositol to Help Get Pregnant?
Individuals concerned about the quality of their eggs, particularly women over age 35 or with a history of ovarian issues such as Polycystic Ovarian Syndrome, may want to consider supplementing with Inositol. Because Inositol is naturally-occurring, it is generally safe for all women seeking to conceive to take in moderation. You should consult with your fertility specialist before beginning taking Inositol.

How much Inositol should I take?
Inositol is safe to take in dosages ranging from 2mg to 10mg daily. Benefits may be seen at the lower end of this dosage spectrum, however your fertility specialist may feel that the larger dosage will be beneficial. Always consult a fertility specialist before beginning supplementation.

Are there Contraindications of Inositol for Fertility?
For women, supplementing with Inositol to boost fertility is generally safe. Because Inositol has been found to decrease testosterone levels, it should not be used by men as a fertility booster. Due to its role in decreasing insulin resistance, Inositol may not be right for certain individuals with pre-existing blood glucose issues.

How successful is Inositol?
Most of the research on Inositol for fertility is in the context of women with polycystic ovary syndrome (PCOS). However, success in this context should not be ignored by women with healthy ovaries. Additionally, Inositol has been acknowledged as a mediator of insulin in the body, which is essential to fertility. Although there is room for further research, the benefits of Inositol are slowly being recognized by the fertility community as a helpful supplement.

MELATONIN
Melatonin is a natural hormone nutrient that is synthesized from the amino acid tryptophan by the pineal gland in the back of the brain. Melatonin also occurs in small amounts in a variety of foods. In the body, melatonin appears to regulate sleep/wake cycles, support normal immune function, and protect cells from free raical damage. Melatonin supports normal immune function by helping maintain the activity of circulating natural killer cells. It also has been found to function as antagonist for stress induced immunosuppression. Melatonin is considered a potent antioxidant that enters all body cells to help prevent free radical damage. In the brain, melatonin is perhaps the most important physiological antioxidant. Due to its lipid and water soluble properties, it can freely cross the blood brain barrier. In vitro studies show the at melatonin is more effective than glutathione inscavenging toxic hydroxyl radicals, and also more efficient than vitamin E in neutralizing peroxyl radicals which can induce DNA damage. Furthermore, melatonin stimulates the main antioxidant enzyme of the brain, glutathione peroxidase. Melatonin capsules may be a useful nutritional adjunct for individuals who wish to support the body’s pineal gland function

CALCIUM L-5- METHYLTETRAHYDROFOLATE
Calcium L-5 Methyltetrahydrofolate is the active form of folate which need not be activated by the variants of folate dependent enzymes. Directly absorbed as L-Methylfolate and directly involved in lowering Homocysteine blood levels. The only form of folate able to cross the blood brain barrier with 100 % bioavailabilty. It is a Hematologic agent (concerned with blood, the blood-forming organs, and blood diseases), which stimulates the hematopoietic system. Childrens, adults and old age require Folic acid to produce healthy red blood cells and prevent anemia. safe as demonstrated by extensive toxicological studies. Calcium L-5 Methyltetrahydrofolate increases the RBC Count and Heamoglobin in anemic patients and pregnancy periods.

Gynefol tablets can be used for Promote egg quality and ovarian function
This unique formulation is highlighted by ingredients, N-Acetylcysteine, Myo Inositol, Calcium L-5-Methyltetrahydrofolate and Melatonin improve egg quality. Of course, , Calcium L-5-Methyltetrahydrofolate is already well-known for its ability to prevent neural tube defects, and it is recommended that all women of child-bearing age take in a sufficient amount of folic acid. But, recent research indicates that when , Calcium L-5-Methyltetrahydrofolate is given in combination with two powerful antioxidants, Myo Inositol and melatonin, egg quality is significantly improved in women undergoing IVF treatments. Recent research also confirms that Myo Inositol works to improve insulin sensitivity, thereby helping to promote optimal ovarian function and cycle regularity in women with PCOS.

GYNEFOL was designed specifically for trying-to-conceive women who are over the age of 30, and for women who have PCOS. However, Gynefol is also intended to optimize egg quality and ovarian function in trying to conceive women of all ages.

The formulation for Gynefol was developed on the basis of a large, and ever-growing, body of scientific literature that explains the underlying causes of poor egg quality and ovarian dysfunction, and points to effective and promising natural ingredients for improving egg quality and ovarian function.

INDICATIONS AND USES
Fertility agents, Polycystic ovarian syndrome, antioxidants, patients who wish to increase their intake of cysteine –derived antioxidants, To increase both extracellular and intra cellular glutathione levels

STORAGE
Store in a cool dry,dark place,away from direct light. Keep out of reach of children.

DOSAGE
Nutritional food supplement (proprietary food)
One tablet daily after meals or as directed by the healthcare professional.

PACKING
Alu alu packing with 10 tablets per strip.

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