API (Active Pharmaceutical Ingredients)



LMF – Calcium L-5-Methyltetrahydrofolate; L-5-MTHF-Ca; L-methylfolate calcium; L-5-Methyltetrahydrofolic acid, calcium salt; [6S]-5-Methyltetrahydrofolic acid, calcium salt.

Molecular weight : 497.52
CAS No: 151533-22-1

Calcium L-5-Methyltetrahydrofolate ( LMF )
LMF – Calcium L-5-Methyltetrahydrofolate, or L-methylfolate is the pure from the naturally-occurring predominant form of folate. It is needed for cell division or cell repair. LMF – Calcium L-5-Methyl Tetrahydrofolate is L-methylfolate, the body’s preferred form of folate. LMF – Calcium L-5-Methyltetrahydrofolate is directly usable by the human Organism, directly involved in lowering homocysteine blood levels, and the only form of folate able to cross the blood-brain barrier.

Properties & Benefits:
LMF – Calcium L-5-Methyltetrahydrofolate has been developed to provide a stable ingredient, readily bioavailable folate vitamer (folic acid is a proviatamin and needs to be activated) Directly usable by the body, independent of genetic variants of folate dependent enzymes (MTHFR-Methylenetetrahydrofolate reductase)

Regulatory Status

  • In 1999 GRAS generally recognized as safe and self affirmation for LMF -(Calcium L-5-Methyltetrahydrofolate).
  • In 2001 New Dietary Ingredient notified as LMF(Calcium L-5-Methyltetrahydrofolate) as a source of the naturally-occurring form of folate.
  • In 2004 EFSA(EU) concludes LMF(Calcium L-5-Methyltetrahydrofolate) as safe for specific nutritional uses, food supplements and normal foods.
  • In 2005 JECFA considers LMF (Calcium L-5-Methyltetrahydrofolate) as safe
  • In 2006 EU Commission published 2006/34/EC and 2006/37/EC with LMF
  • In united states pharmacopeia USP 38 the LMF is been approved in dietary supplements.

Fields of Application

Pre conception & Pregnancy
Health authorities throughout the world encourage women of childbearing age to take folate supplements, Especially the occurrence of neural tube defects (NTD’s), a major and common birth defect, is directly linked to insufficient folate levels during preconception and early pregnancy. NTD’s are congenital malformations which result when the neural plate fails to close during the formation of the neural tube during early embryonic development. Spina bifida and anencephaly are the mose frequently occuring forms of neural tube defects.

Infants & Kids & Adolescents
Sufficient folate levels are critical throughout your entire life. Especially in life phases of growth, cell division and repair, as folates are needed for the production of DNA building blocks and cell integrity.

Adults & Elderly
Sufficient folate levels are critical throughout your entire life. Less than optimal folate nutrition has been implicated in the etiology of a variety of disorders including anemia, Neural tube defects (NTD’s), various forms of cardiovascular disease (CVD), Alzheimer’s disease and osteoporoses. The homocysteine-lowering effect of folate is said to play an important role in prevention of some of these disorders.

Heart Health
An increased homocysteine blood level is regarded as a risk factor for cardiovascular diseases. LMF (Calcium L-5-Methyltetrahydrofolate) is positively involved in this process by increasing folate blood levels and by decreasing homocysteine blood level. L-methylfolate restores endothelial function in familial hypercholesterolemia. In addition: L-methylfolate directly interacts with nitric oxide synthase (NOS) to promote nitric oxide (vs. superoxide) production, with reduces oxidative stress.

Clinical studies point out that there could be an association between mental vitality, dementia, Alzheimer’s disease and the folate status of the brain. In addition, there might be a direct link between cerebral folate status and depression.

Cognitive Impairment & Dementia & Alzheimer
The association between mental vitality, dementia, Alzheimer’s disease and the folate status of the brain.

Folate deficiency is assumed to reduce the cell’s capacity for DNA synthesis and repair. Impaired DNA synthesis would become most obvious in those cells undergoing rapid division.

DMF, C.O.A with all details available.

Keep in a well closed air tight container, protect from light and place it in a cool dry place.

Available as per consumer requirements in varous packing

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