Formulated Dosage Forms

PENTOSAN POLYSULPHATE SODIUM 100MG CAPSULES

PENTOSSAN -100
COMPOSITION Each Hard Gelatin Capsule Contains
Pentosan polysulphate sodium 100mg
PRODUCT DESCRIPTION AND MECHANISM :
Pentosan is a semi-synthetic (man-made) drug that resembles the anticoagulant (“blood thinner”) heparin and is used for treating the symptoms of interstitial cystitis. Interstitial cystitis is a condition, usually of unknown cause, in which there is inflammation of the urinary bladder that most frequently causes pelvic pain and frequent urination. The exact mechanism whereby pentosan reduces the symptoms of interstitial cystitis also is unknown; however, scientists believe that pentosan may coat the lining of the bladder and prevent irritating substances in the urine from reaching the cells of the lining. The FDA approved pentosan in September 1996.

PREPARATIONS: Capsules: 100 mg.

PRESCRIBED FOR: Pentosan is used for relieving bladder pain caused by interstitial cystitis.

DOSING:
The recommended dose of pentosan is 100 mg three times daily (every 8 hours) taken at least one hour before or two hours after meals so that food does not retard its absorption. Patients should be evaluated after 3 months, and treatment may be continued for another three months if patients have not improved and they are tolerating pentosan. As directed by the Physician.

DRUG INTERACTIONS:
Pentosan resembles heparin and it affects the ability of blood to clot. Therefore, it can cause bleeding and if combined with other drugs that also cause bleeding (anticoagulants) the risk of bleeding may increase. Examples of drugs that cause bleeding include heparin, streptokinase, aspirin, nonsteroidal anti-inflammatory drugs (for example, ibuprofen), and warfarin (Coumadin).

SIDE EFFECTS:
The most common side effects of pentosan are stomach upset, diarrhea, nausea, headache, rash, abdominal pain, hair loss and dizziness. Some patients may develop abnormalities of liver tests in the blood. Bleeding from the rectum and other areas also may occur.

STORAGE:
Store in a cool dry,dark place,away from direct light. Keep out of reach of children. Stored at room temperature, between 15 C to 30 C (59 F to 86 F).

PACKING:
Alu Alu packing with 10 capsules per strip.

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